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The Twelfth Card is a two-day cat-and-mouse chase through the streets of uptown Manhattan as quadriplegic detective Lincoln Rhyme and Amelia Sachs try to outguess Thompson Boyd, by all appearances a nondescript, innocuous man, but one whose past has turned him into a killing machine as unfeeling and cunning as a wolf. Boyd is after Geneva Settle, a high school girl from Harlem, and it's up to Lincoln and Amelia to figure out why.

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